6-甲基-5-((三甲基甲硅烷基)乙炔)嘧啶-2,4-二醇合成路线 （共 2 条）
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in ethyl acetate
T=10 - 25°C; 16 h; Inert atmosphere;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
Location in patent: Page/Page column 188 ;
WO 2011/019405 A1
反应条件
1: acetic acid; N-iodo-succinimide / 7 h
2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / ethyl acetate / 16 h / 10 - 25 °C / Inert atmosphere
View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
WO 2011/019405 A1
