3-甲基-4(1H)-喹啉酮合成路线 （共 9 条）
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydroxide in tetrachloromethane T=60°C; 72 h;
参考文献
Giorgi-Renault, Sylviane; Renault, Jean; Bukovec, Zjelka
Synthesis, 1984 , # 6 p. 491 - 493
反应条件
trichlorophosphate T=105°C; 1 h;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
mineral oil
T=270 - 280°C;
参考文献
Steck et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 132
反应条件
1: aq. NaOH / 2.5 h / Heating
2: 231 mg / diphenyl ether / 1 h / 250 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: 2.42 g / diphenyl ether / 1 h / 250 °C
2: aq. NaOH / 2.5 h / Heating
3: 231 mg / diphenyl ether / 1 h / 250 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: p-TsOH*H2O / toluene / Heating
2: 2.42 g / diphenyl ether / 1 h / 250 °C
3: aq. NaOH / 2.5 h / Heating
4: 231 mg / diphenyl ether / 1 h / 250 °C
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
paraffin oil
T=260°C;
参考文献
I.G. Farbenind.
Patent: DE748540 , 1941 ;
DRP/DRBP Org.Chem.
反应条件
methanol; sodium methylate
T=100°C; unter Druck.;
参考文献
Drummond; Lahey
Australian Journal of Scientific Research, Series A: Physical Sciences, 1949 , vol. 2, p. 630,635
反应条件
1: sulfuric acid; nitric acid
2: phosphoryl chloride
3: Raney nickel; ethanol / Hydrogenation
4: aqueous hydrochloric acid; aqueous sodium nitrite / Erw. der Rktlsg. mit Kupfer(I)-chlorid und wss. Salzsaeure
View Scheme
参考文献
Adams; Hey
Journal of the Chemical Society, 1950 , p. 2092,2095
