1-(2-氟-3-羟基-6-硝基苯基)丙烷-2-酮合成路线 （共 7 条）
反应条件
acetic anhydride in acetic acid T=20 - 100°C; 0.5 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/9542 A2, 2004 ;
Location in patent: Page 37 ;
WO 2004/009542 A2
反应条件
sodium acetate in N,N-dimethyl-formamide T=100°C; 12 h;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76044 A1, 2009 ;
Location in patent: Page/Page column 27-28 ;
US 20090076044 A1
反应条件
pyridine hydrochloride T=20 - 180°C; 1.25 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/9542 A2, 2004 ;
Location in patent: Page 35 ;
WO 2004/009542 A2
反应条件
pyridine hydrochloride T=20 - 180°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/9542 A2, 2004 ;
Location in patent: Page 37 ;
WO 2004/009542 A2
反应条件
sulfuric acid; acetic acid in water T=97°C; 3.5 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/53221 A2, 2008 ;
Location in patent: Page/Page column 45 ;
WO 2008/053221 A2
反应条件
sulfuric acid; acetic acid in water T=90°C; 4 h; Product distribution / selectivity;
参考文献
WO2008/53221 A2, ;
Page/Page column 43 ;
WO 2008/053221 A2
反应条件
sodium dithionite in water T=0 - 30°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/9542 A2, 2004 ;
Location in patent: Page 35 ;
WO 2004/009542 A2
