3-氨基-5-(4-甲氧基苯基)噻吩-2-羧酸合成路线 （共 4 条）
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
反应条件
1: With potassium hydroxide in ethanol; water
4 h; Reflux;
2: With phosphoric acid in water
参考文献
Abdillahi, Ismail; Revelant, Germain; Datoussaid, Yazid; Kirsch, Gilbert
Synthesis, 2010 , # 15 art. no. Z07410SS, p. 2543 - 2546
反应条件
1: sodium; methanol / 0.5 h / |Reflux
2: potassium hydroxide / methanol; water / 3 h / |Reflux
View Scheme
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
反应条件
1.1: trichlorophosphate / 0.25 h / 25 °C
1.2: 0.5 h / 20 - 60 °C
1.3: 0.5 h
2.1: sodium; methanol / 0.5 h / |Reflux
3.1: potassium hydroxide / methanol; water / 3 h / |Reflux
View Scheme
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
