2-氨基-4-噻唑乙酸甲酯合成路线 （共 5 条）
反应条件
1: With sulfuric acid in methanol T=0°C; Reflux; 2: With sodium hydrogencarbonate pH=8 - 9;
参考文献
ORCHID RESEARCH LABORATORIES LIMITED
Patent: WO2007/17728 A2, 2007 ;
Location in patent: Page/Page column 15 ;
反应条件
in methanol; benzene T=20°C;
参考文献
WO2004/33423 A2, ;
Page 25-27 ;
反应条件
in ethanol 4 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 1255 - 1257
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=0 - 20°C; 10 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
Location in patent: Page/Page column 74 ;
WO 2013/019621 A1
反应条件
1: triethylamine / dichloromethane / 15 h
2: methanol; sodium hydroxide / 1 h
View Scheme
参考文献
Bolchi, Cristiano; Pallavicini, Marco; Bernini, Sergio K.; Chiodini, Giuseppe; Corsini, Alberto; Ferri, Nicola; Fumagalli, Laura; Straniero, Valentina; Valoti, Ermanno
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5408 - 5412
