beta-甲基-2-硝基-苯乙醇合成路线 （共 12 条）
反应条件
hydrogen; tris(triphenylphosphine)ruthenium(II) chloride; rhodium in toluene 1.) RT, 11 h, 2.) reflux, 6 h;
参考文献
Tsuji, Yasushi; Kotachi, Shinji; Huh, Keun-Tae; Watanabe, Yoshihisa
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 580 - 584
反应条件
N-benzyl-trimethylammonium hydroxide in methanol
6 h; Heating;
参考文献
Bhushan, Kumar R.
Synlett, 2006 , # 13 p. 2130 - 2132
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
T=0 - 20°C; 2 h; Inert atmosphere;
2: With sodium hydroxide in tetrahydrofuran; water
T=20 - 40°C; 1 h;
3: With dihydrogen peroxide in tetrahydrofuran; water
T=20 - 30°C;
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
N-benzyl-trimethylammonium hydroxide in methanol
6 h; Heating;
参考文献
Bhushan, Kumar R.; DeLisi, Charles; Laursen, Richard A.
Tetrahedron Letters, 2003 , vol. 44, # 47 p. 8585 - 8588
反应条件
1.1: 48 percent / ammonia; H2S / dioxane / 35 - 40 °C
2.1: NaNO2; AcOH; H2SO4 / H2O / 1 h / 20 - 25 °C
2.2: 76 percent / Cu2O / ethanol; H2O / 1.5 h / 20 °C
3.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
4.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
4.2: urea / H2O / 0.08 h
4.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
5.1: 2 percent / NaCN / dimethylsulfoxide / 2 h / 20 °C
View Scheme
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
1.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
2.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
2.2: urea / H2O / 0.08 h
2.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
3.1: 2 percent / NaCN / dimethylsulfoxide / 2 h / 20 °C
View Scheme
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
1.1: NaNO2; AcOH; H2SO4 / H2O / 1 h / 20 - 25 °C
1.2: 76 percent / Cu2O / ethanol; H2O / 1.5 h / 20 °C
2.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
3.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
3.2: urea / H2O / 0.08 h
3.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
4.1: 2 percent / NaCN / dimethylsulfoxide / 2 h / 20 °C
View Scheme
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
sodium cyanide in dimethyl sulfoxide
T=20°C; 2 h;
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
sodium cyanide in dimethyl sulfoxide
T=20°C; 2 h;
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
1.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
1.2: urea / H2O / 0.08 h
1.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
2.1: 2 percent / NaCN / dimethylsulfoxide / 2 h / 20 °C
View Scheme
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
