反应条件
1.1: N,N-dimethyl-formamide / 20 h / 20 °C
2.1: pyridine / 20 °C
3.1: dimethyl sulfoxide; trifluoroacetic anhydride / tetrahydrofuran / 2.75 h / -20 - -15 °C
3.2: 0.33 h
4.1: diethyl ether / 2 h / -78 °C / |Inert atmosphere
4.2: 0.75 h / 20 °C
5.1: pyridine / 1.67 h / 0 °C / |Inert atmosphere
6.1: diethylamino-sulfur trifluoride / 1 h / -20 °C / |Inert atmosphere
View Scheme
参考文献
GILEAD SCIENCES, INC.; Delaney, William E.; Link, John O.; Mo, Hongmei; Oldach, David W.; Ray, Adrian S.; Watkins, William J.; Yang, Cheng Yong; Zhong, Weidong
Patent: US2013/273005 A1, 2013 ;
