5-(3-甲氧基苯基)戊酸合成路线 （共 24 条）
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 12 h / 20 °C
2.1: hydrogen / palladium 10 on activated carbon / ethanol / 12 h
View Scheme
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
反应条件
1: 1.) t-BuOK, 2.) aq. KOH / 1.) t-BuOH, 4 h, 2.) reflux, 12 h
2: 23 g / hydrogen / 10percent Pd-C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Sangwan, Naresh K.; Rastogi, Shri Nivas
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 2 p. 140 - 143
反应条件
human intestinal bacteria in methanol
T=37°C; 48 h; Further byproducts given;
参考文献
Meselhy, Meselhy R.; Nakamura, Norio; Hattori, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 888 - 893
反应条件
1.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 2 h / 20 °C / 2585.81 Torr
2.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 15 h / -5 - 20 °C
2.2: pH 2 - 3
View Scheme
参考文献
SCHERING CORPORATION; COBURN, Craig, A.; LAVEY, Brian, J.; DWYER, Michael, P.; KOZLOWSKI, Joseph, A.; ROSENBLUM, Stuart, B.
Patent: WO2012/50848 A1, 2012 ;
反应条件
1: acetonitrile / |Reflux
2: lithium hexamethyldisilazane
3: hydrogen; platinum on activated charcoal / methanol
View Scheme
参考文献
Kammath, Viju Balachandran; Solomek, Tomas; Ngoy, Bokolombe Pitchou; Heger, Dominik; Klan, Petr; Rubina, Marina; Givens, Richard S.
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1718 - 1729
反应条件
C3 antibody
pH 8.5; rate of hydrolysis at other pH-values; Rate constantMechanism;
参考文献
Khalaf, Abedawn I.; Proctor, George R.; Suckling, Colin J.; Bence, Laura H.; Irvine, June I.; Stimson, William H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 12 p. 1475 - 1482
反应条件
1: 99 percent / Br2 / CHCl3 / 2 h / Ambient temperature
2: 60 percent / polyphosphoric acid / 8 h / 55 °C
3: 96 percent / H2, triethylamine / 7percent Pd-C / ethanol / 3.5 h / Ambient temperature
4: 98 percent / pyridinium chloride / 1 h / 200 °C
5: 95 percent / pyridine / 5 h / Ambient temperature
6: 66 percent / Br2 / CCl4 / 3 h / Ambient temperature
7: 74 percent / LiCl / dimethylformamide / 3 h / Heating
8: K3PO4 / dimethylsulfoxide / 0.5 h / 60 °C
9: 97 percent / 2 M aq.KOH / ethanol
10: 60 percent / acetonitrile / 0.17 h / Ambient temperature; Irradiation
11: 31 percent / benzene / 2 h / Heating
View Scheme
参考文献
Horaguchi, Takaaki; Hasegawa, Eietsu; Shimizu, Takahachi; Tanemura, Kiyoshi; Suzuki, Tsuneo
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 365 - 369
反应条件
1: polyphosphoric acid
2: acetic acid; bromine
3: lithium chloride / N,N-dimethyl-formamide / |Reflux
4: boron tribromide / dichloromethane / |Reflux
5: hydroxylamine hydrochloride; pyridine / ethanol
6: triethylamine / dichloromethane / 0.17 h / 0 °C
7: toluene; diethyl ether / 1.5 h / -20 - 0 °C / |Inert atmosphere
View Scheme
参考文献
Kang, Zhi-Yun; Zhang, Qing-Jian; Chen, Ruo-Yun; Zhang, Pei-Cheng; Yu, De-Quan
Journal of Asian Natural Products Research, 2013 , vol. 15, # 8 p. 840 - 848
反应条件
1: methanesulfonic acid; phosphorous pentoxide / 12 h / Inert atmosphere
2: nitric acid; acetic anhydride / acetic acid / 3 h / -78 °C
View Scheme
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
反应条件
1: phosphorous pentoxide; methanesulfonic acid / 12 h / |Inert atmosphere
2: acetic acid; acetic anhydride; nitric acid / -10 °C
View Scheme
参考文献
Tanpure, Rajendra P.; George, Clinton S.; Sriram, Madhavi; Strecker, Tracy E.; Tidmore, Justin K.; Hamel, Ernest; Charlton-Sevcik, Amanda K.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
MedChemComm, 2012 , vol. 3, # 6 p. 720 - 724
