5-(3-甲氧基苯基)戊酸合成路线 （共 24 条）
反应条件
1: methanesulfonic acid; phosphorous pentoxide / 12 h / Inert atmosphere
2: nitric acid; acetic anhydride / acetic acid / 3 h / -78 °C
View Scheme
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
反应条件
1: PPA / chlorobenzene / 15 h / 80 °C
2: bromine / diethyl ether / 2 h
View Scheme
参考文献
SCHERING CORPORATION; COBURN, Craig, A.; LAVEY, Brian, J.; DWYER, Michael, P.; KOZLOWSKI, Joseph, A.; ROSENBLUM, Stuart, B.
Patent: WO2012/50848 A1, 2012 ;
反应条件
1: methanesulfonic acid; phosphorous pentoxide
2: AlCl3, aluminium chloride / benzene / |Reflux
3: copper(ll) bromide / ethyl acetate; chloroform / |Reflux
4: silver(l) oxide / acetonitrile / 60 °C
5: acetonitrile-D3; water-d2 / |Photolysis
View Scheme
参考文献
Kammath, Viju Balachandran; Solomek, Tomas; Ngoy, Bokolombe Pitchou; Heger, Dominik; Klan, Petr; Rubina, Marina; Givens, Richard S.
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1718 - 1729
反应条件
1: methanesulfonic acid; phosphorous pentoxide
2: AlCl3, aluminium chloride / benzene / |Reflux
3: potassium carbonate / acetonitrile / 20 °C
4: potassium permanganate / benzene / |Reflux; |Dean-Stark
5: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C
6: acetonitrile-D3; water-d2 / |Photolysis
View Scheme
参考文献
Kammath, Viju Balachandran; Solomek, Tomas; Ngoy, Bokolombe Pitchou; Heger, Dominik; Klan, Petr; Rubina, Marina; Givens, Richard S.
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1718 - 1729
