2-甲氧基苯并环庚-5-酮合成路线 （共 42 条）
反应条件
1.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 15 h / -5 - 20 °C 1.2: pH 2 - 3 2.1: PPA / chlorobenzene / 15 h / 80 °C View Scheme
反应条件
1: acetonitrile / |Reflux 2: lithium hexamethyldisilazane 3: hydrogen; platinum on activated charcoal / methanol 4: methanesulfonic acid; phosphorous pentoxide View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 5 p. 1718 - 1729
反应条件
sodium hydroxide in tetrahydrofuran 22 h; Heating; Yield given. Title compound not separated from byproducts;
参考文献
Journal of Chemical Research, Miniprint, , # 11 p. 2856 - 2876
反应条件
1: LiAlH4 / diethyl ether 2: TsOH / benzene 3: NBS, (PhCO)2O2 / CCl4 / Irradiation 4: SeO2, aq. KH2PO4 / dioxane 5: Ag2O, aq. NaOH View Scheme
参考文献
Srivastava,K.C.; Dev,S.
Tetrahedron, 1972 , vol. 28, p. 1083 - 1091
反应条件
1: 98 percent / NaBH4 / methanol; H2O / 0 °C 2: 89 percent / DMSO View Scheme
参考文献
Srivastava,K.C.; Dev,S.
Tetrahedron, 1972 , vol. 28, p. 1083 - 1091
反应条件
bromine; lithium chloride 1.) carbon tetrachloride, reflux, 1 h, 2.) DMF, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hicks, Martin G.; Jones, Gurnos; Sheikh, Hamid
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 10 p. 2297 - 2304
反应条件
1: acetic acid; bromine
2: lithium chloride / N,N-dimethyl-formamide / |Reflux
3: boron tribromide / dichloromethane / |Reflux
4: hydroxylamine hydrochloride; pyridine / ethanol
5: triethylamine / dichloromethane / 0.17 h / 0 °C
6: toluene; diethyl ether / 1.5 h / -20 - 0 °C / |Inert atmosphere
View Scheme
参考文献
Kang, Zhi-Yun; Zhang, Qing-Jian; Chen, Ruo-Yun; Zhang, Pei-Cheng; Yu, De-Quan
Journal of Asian Natural Products Research, 2013 , vol. 15, # 8 p. 840 - 848
反应条件
nitric acid; acetic anhydride in acetic acid
T=-78°C; 3 h;
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
Location in patent: Page/Page column 21 ;
反应条件
nitric acid; acetic anhydride in acetic acid
T=-78°C; 3 h;
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
Location in patent: Page/Page column 21 ;
反应条件
bromine in diethyl ether
T=0 - 30°C; 2 h;
参考文献
Maiti, Swaraj B.; Ray Chaudhuri, S. R.; Chatterjee, Amareshwar
Synthesis, 1987 , # 9 p. 806 - 809
