2,5,7-三甲基茚满-1-酮合成路线 （共 12 条）
反应条件
sodium tetrahydroborate; magnesium sulfate in tetrahydrofuran; methanol
参考文献
Hoechst Aktiengesellschaft
Patent: US5374752 A1, 1994 ;
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran; methanol T=20°C; 24 h; 2: With phosphorous pentoxide in benzene 1 h; Heating;
参考文献
Izmer, Vyacheslav V.; Sorokin, Denis A.; Kuz'Mina, Lyudmila G.; Churakov, Andrei V.; Howard, Judith A.K.; Voskoboynikov, Alexander Z.
Journal of Organometallic Chemistry, 2005 , vol. 690, # 4 p. 1067 - 1079
反应条件
sodium tetrahydroborate; magnesium sulfate in tetrahydrofuran; methanol
参考文献
Hoechst Aktiengesellschaft
Patent: US5374752 A1, 1994 ;
反应条件
scandium tris(trifluoromethanesulfonate) in nitromethane
T=100°C; Friedel-Crafts acylation; 0.5 h;
参考文献
Fillion, Eric; Lou, Tiantong; Liao, E-Ting; Wilsily, Ashraf
Organic Syntheses, 2012 , vol. 89, p. 115 - 125
反应条件
PPA
T=100°C; Acylation; Cyclization; 4 h;
参考文献
Finkielsztein, Liliana M.; Alesso, Elba N.; Lantano, Beatriz; Aguirre, Jose M.; Iglesias, Graciela Y. Moltrasio
Journal of Chemical Research, Miniprint, 1999 , # 6 p. 1561 - 1566
反应条件
1.1: piperidinium acetate / ethanol / 0.5 h
1.2: 62 percent / NaBH3CN / ethanol / 0 - 20 °C
2.1: 38 percent / K2CO3 / dimethylformamide
3.1: 87 percent / Sc(OTf)3 / nitromethane / 0.5 h / 100 °C
View Scheme
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
1: 38 percent / K2CO3 / dimethylformamide
2: 87 percent / Sc(OTf)3 / nitromethane / 0.5 h / 100 °C
View Scheme
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
1: SOCl2 / 24 h / 20 °C
2: 64.7 g / AlCl3 / CH2Cl2 / 1.5 h / Heating
View Scheme
参考文献
Izmer, Vyacheslav V.; Sorokin, Denis A.; Kuz'Mina, Lyudmila G.; Churakov, Andrei V.; Howard, Judith A.K.; Voskoboynikov, Alexander Z.
Journal of Organometallic Chemistry, 2005 , vol. 690, # 4 p. 1067 - 1079
反应条件
1: K2CO3 / dimethylformamide / 10 h / 150 °C
2: concd. HCl / acetic acid / 24 h / Heating
3: 0.88 g / polyphosphoric acid / 3 h / 100 °C
View Scheme
参考文献
Fukuoka, Masamichi; Yoshihira, Kunitoshi; Natori, Shinsaku; Mihashi, Kunihide; Nishi, Masatoshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3113 - 3128
反应条件
1: concd. HCl / acetic acid / 24 h / Heating
2: 0.88 g / polyphosphoric acid / 3 h / 100 °C
View Scheme
参考文献
Fukuoka, Masamichi; Yoshihira, Kunitoshi; Natori, Shinsaku; Mihashi, Kunihide; Nishi, Masatoshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3113 - 3128
