4-氨甲基-1-(正丁基)哌啶合成路线 （共 5 条）
反应条件
sodium hydroxide; potassium carbonate in toluene
参考文献
SmithKline Corporation p.l.c.
Patent: US6331631 B1, 2001 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=45°C; Reduction;
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 4 p. 329 - 341
European Journal of Medicinal Chemistry, , vol. 34, # 11 p. 977 - 989
反应条件
in acetonitrile T=0 - 20°C; Alkylation;
参考文献
Lopez-Rodriguez, Maria L.; Benhamu, Bellinda; Viso, Alma; Morcillo, M.Jose; Murcia, Marta; Orensanz, Luis; Alfaro, M.Jose; Martin, M.Isabel
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2271 - 2281
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4121 - 4123
反应条件
1: K2CO3 / ethanol / Heating 2: P2O5 / 180 °C 3: LiAlH4 / diethyl ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4121 - 4123
