1-甲基-5H-吡啶并(4,3-b)吲哚-3-羧酸合成路线 （共 23 条）
反应条件
1: 20percent aqueous NaOH / ethanol / 12 h / Heating
2: 86 percent / diethyl ether; methanol; CHCl3 / 0.17 h / 0 °C
3: 86 percent / AcOH, polyphosphoric acid / acetonitrile / 12 h / Ambient temperature
4: 77 percent / NH2OH*HCl, NaOAc / ethanol / 1 h / Heating
5: 51 percent / xylene / 24 h / Heating
6: 95 percent / 10percent aqueous NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Hibino, Satoshi; Sugino, Eiichi; Kuwada, Takeshi; Ogura, Naoki; Sato, Kohichi; Choshi, Tominari
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5917 - 5921
反应条件
1: 1.5 h / 180 °C
2: 20percent aqueous NaOH / ethanol / 12 h / Heating
3: 86 percent / diethyl ether; methanol; CHCl3 / 0.17 h / 0 °C
4: 86 percent / AcOH, polyphosphoric acid / acetonitrile / 12 h / Ambient temperature
5: 77 percent / NH2OH*HCl, NaOAc / ethanol / 1 h / Heating
6: 51 percent / xylene / 24 h / Heating
7: 95 percent / 10percent aqueous NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Hibino, Satoshi; Sugino, Eiichi; Kuwada, Takeshi; Ogura, Naoki; Sato, Kohichi; Choshi, Tominari
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5917 - 5921
反应条件
1: 20percent aqueous NaOH / ethanol / 14 h / Heating
2: pyridine / 12 h / Heating
3: 86 percent / diethyl ether; methanol; CHCl3 / 0.17 h / 0 °C
4: 86 percent / AcOH, polyphosphoric acid / acetonitrile / 12 h / Ambient temperature
5: 77 percent / NH2OH*HCl, NaOAc / ethanol / 1 h / Heating
6: 51 percent / xylene / 24 h / Heating
7: 95 percent / 10percent aqueous NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Hibino, Satoshi; Sugino, Eiichi; Kuwada, Takeshi; Ogura, Naoki; Sato, Kohichi; Choshi, Tominari
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5917 - 5921
反应条件
1: ethanol / 1 h / 20 °C
2: sodium / ethanol; 20 deg C; 3 days;
3: 95 percent / Na2CO3 / H2O / Heating
4: 87 percent / thionyl chloride / Heating
5: 98 percent / sulfur / xylene / Heating; lead tetraacetate as reagent in pyridine;
6: 96 percent / aq.NaOH / ethanol / Heating
View Scheme
参考文献
Akimoto, Hiroshi; Kawai, Akiyoshi; Nomura; Hiroaki
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, p. 123 - 130
反应条件
1: sodium / ethanol; 20 deg C; 3 days;
2: 95 percent / Na2CO3 / H2O / Heating
3: 87 percent / thionyl chloride / Heating
4: 98 percent / sulfur / xylene / Heating; lead tetraacetate as reagent in pyridine;
5: 96 percent / aq.NaOH / ethanol / Heating
View Scheme
参考文献
Akimoto, Hiroshi; Kawai, Akiyoshi; Nomura; Hiroaki
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, p. 123 - 130
反应条件
1: 53 percent / t-BuLi / diethyl ether
2: 70 percent / NaOEt / ethanol / -15 °C
3: 85 percent / CH2Cl2 / Ambient temperature
4: 85 percent / toluene / 12 h / 160 °C
5: 70 percent / HCOOH / Heating
6: 98 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Almendros, Pedro; Fresneda, Pilar M.
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4701 - 4704
反应条件
1: 70 percent / NaOEt / ethanol / -15 °C
2: 85 percent / CH2Cl2 / Ambient temperature
3: 85 percent / toluene / 12 h / 160 °C
4: 70 percent / HCOOH / Heating
5: 98 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Almendros, Pedro; Fresneda, Pilar M.
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4701 - 4704
反应条件
1: 85 percent / CH2Cl2 / Ambient temperature
2: 85 percent / toluene / 12 h / 160 °C
3: 70 percent / HCOOH / Heating
4: 98 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Almendros, Pedro; Fresneda, Pilar M.
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4701 - 4704
反应条件
1: 70 percent / HCOOH / Heating
2: 98 percent / LiOH / H2O; tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Molina, Pedro; Almendros, Pedro; Fresneda, Pilar M.
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4701 - 4704
反应条件
1: 87 percent / thionyl chloride / Heating
2: 98 percent / sulfur / xylene / Heating; lead tetraacetate as reagent in pyridine;
3: 96 percent / aq.NaOH / ethanol / Heating
View Scheme
参考文献
Akimoto, Hiroshi; Kawai, Akiyoshi; Nomura; Hiroaki
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, p. 123 - 130
