1-(3-溴苯基)-4-氯-1H-吡唑并[3,4-d]嘧啶合成路线 (共 5 条)
反应条件
1: triethylamine / acetonitrile / 16 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: triethylamine / acetonitrile / 16 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: ethanol / 4 h / Heating
2: H2O / 24 h / Heating
3: POCl3; DMF / 4 h / Heating
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
反应条件
N,N-dimethyl-formamide; trichlorophosphate
4 h; Heating;
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
反应条件
1: H2O / 24 h / Heating
2: POCl3; DMF / 4 h / Heating
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125