alpha-chloropyridine; trifluoromethylsulfonic anhydride in dichloromethane
T=-78 - 140°C; Bischler-Napieralski reaction; Inert atmosphereMicrowave irradiation at 140 °C for 5 min;
参考文献
Movassaghi, Mohammad; Hill, Matthew D.
Organic Letters, 2008 , vol. 10, # 16 p. 3485 - 3488
1: 97 percent / 10percent aq. NaOH / CH2Cl2 / 0.25 h
2: polyphosphoric acid / 4 h / 140 °C
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
1: 97 percent / 10percent aq. NaOH / CH2Cl2 / 0.25 h
2: polyphosphoric acid / 4 h / 140 °C
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
