N,5-二甲基-2-硝基苯胺合成路线 （共 23 条）
反应条件
1: ethanol
2: copper (II)-sulfate; aqueous acetic acid
View Scheme
参考文献
Mangini; Colonna
Gazzetta Chimica Italiana, 1938 , vol. 68, p. 708,713
反应条件
sodium hydroxide in ethanol
T=20°C; 48 h;
参考文献
Garkushenko; Poendaev; Vorontsova; Sagitullina
Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 4 p. 470 - 481
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
Ambient temperature;
参考文献
Brown, Samuel A.; Rizzo, Carmelo J.
Synthetic Communications, 1996 , vol. 26, # 21 p. 4065 - 4080
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
Heating / reflux; Product distribution / selectivity;
参考文献
Egle, Ian; Isaac, Methvin; Urbanek, Rebecca; McLaren, Frances M.; Walsh, Sally B.; Steelman, Gary B.; Brown, Dean G.; Nugiel, David; Chen, Deborah W.; Slassi, Abdelmalik; Ma, Fupeng
Patent: US2009/192169 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
反应条件
1: acetic acid; acetic acid anhydride; nitric acid / und Erhitzen des Reaktionsprodukts mit wss.Schwefelsaeure
2: pyridine
3: aqueous NaOH-solution
4: acetic acid; sulfuric acid
View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
反应条件
potassium hydroxide in acetone
8 h; Heating; Yield given;
参考文献
Skibo, Edward B.; Islam, Imadul; Heileman, Matthew J.; Schulz, William G.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 78 - 92
参考文献
Brady; Reynolds
Journal of the Chemical Society, 1928 , p. 198,199
Journal of the Chemical Society, 1931 , p. 1274,1277
参考文献
Fischer,O.; Rigaud
Chemische Berichte, 1902 , vol. 35, p. 1259
反应条件
copper(II) sulfate; acetic acid
参考文献
Mangini; Colonna
Gazzetta Chimica Italiana, 1938 , vol. 68, p. 708,713
反应条件
1: silver oxide; benzene
2: water / 165 °C
View Scheme
参考文献
Brady; Reynolds
Journal of the Chemical Society, 1928 , p. 198,199
Journal of the Chemical Society, 1931 , p. 1274,1277
