二乙基[二溴(氟)甲基]膦酸酯合成路线 （共 12 条）
反应条件
hydrogenchloride; n-butyllithium; chloro-trimethyl-silane 1.) THF, hexane, -78 deg C, 10 min, 2.) -60 deg C, 15 min; 20 deg C, 10 min, 3.) CH2Cl2, 10 min; Yield given. Multistep reaction;
参考文献
Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Tetrahedron, 1997 , vol. 53, # 18 p. 6391 - 6400
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 2.) hexane, THF, -78 deg C to -40 deg C 2: ethanol, 2 N HCl, water / hexane; tetrahydrofuran; CH2Cl2 / -40 °C View Scheme
参考文献
Patois, Carl; Savignac, Philippe
Phosphorus, Sulfur and Silicon and the Related Elements, 1993 , vol. 77, # 1-4 p. 163
反应条件
n-butyllithium; chloro-trimethyl-silane; ethanol 1.) 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, -78 deg C, 30 min, 3.) -78 deg C to 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Tetrahedron, 1997 , vol. 53, # 18 p. 6391 - 6400
反应条件
n-butyllithium; chloro-trimethyl-silane; ethanol 1.) 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, -78 deg C, 30 min, 3.) -78 deg C to 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Tetrahedron, 1997 , vol. 53, # 18 p. 6391 - 6400
反应条件
potassium fluoride; ethanol in triglyme (triethylene glycol dimethyl ether) T=20°C;
参考文献
Flynn, Richard M.; Burton, Donald J.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 10 p. 815 - 828
反应条件
potassium fluoride in triglyme (triethylene glycol dimethyl ether) T=20°C;
参考文献
Flynn, Richard M.; Burton, Donald J.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 10 p. 815 - 828
反应条件
potassium fluoride; ethanol in triglyme (triethylene glycol dimethyl ether) T=20°C;
参考文献
Journal of Fluorine Chemistry, , vol. 132, # 10 p. 815 - 828
反应条件
potassium fluoride in triglyme (triethylene glycol dimethyl ether) T=20°C;
参考文献
Journal of Fluorine Chemistry, , vol. 132, # 10 p. 815 - 828
反应条件
in hexane
264 h; Ambient temperatureIrradiation;
参考文献
Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Tetrahedron, 1996 , vol. 52, # 45 p. 14199 - 14216
反应条件
1: n-BuLi / tetrahydrofuran / -90 °C
View Scheme
参考文献
Iorga, Bogdan; Eymery, Frederic; Savignac, Philippe
Tetrahedron Letters, 1998 , vol. 39, # 25 p. 4477 - 4480
