4’-溴-2’-甲基苯乙酮合成路线 （共 11 条）
反应条件
1: in diethyl ether T=20°C; 5.5 h; 2: With water in diethyl ether T=0°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/79836 A2, 2008 ;
Location in patent: Page/Page column 94 ;
WO 2008/079836 A2
反应条件
in diethyl ether T=20°C; 1.5 h;
参考文献
PFIZER INC.
Patent: WO2003/95441 A1, 2003 ;
Location in patent: Page/Page column 41 ;
反应条件
1: in tetrahydrofuran T=-60 - 20°C; 0.833333 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
Chen, Shaoqing; Huby, Nicholas J.S.; Kong, Norman; Moliterni, Jonh Anthony; Morales, Omar Jose
Patent: US2009/170920 A1, 2009 ;
Location in patent: Page/Page column 17 ;
US 20090170920 A1
反应条件
aluminium trichloride in dichloromethane Ambient temperature;
参考文献
Yu; Chong, Yoochul; Kayyem, Jon Faiz; Gozin, Michael
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2070 - 2079
反应条件
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 2: diethyl ether / 18 h / 0 - 40 °C View Scheme
反应条件
aluminium trichloride in carbon disulfide Title compound not separated from byproducts;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 7 p. 2809 - 2820
反应条件
aluminium trichloride
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 43, p. 359
反应条件
diethyl ether Erhitzen des vom Aether befreiten Reaktionsgemisches und anschliessend Erwaermen mit wss. Essigsaeure;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 546, p. 277,291
参考文献
Journal of Organic Chemistry, , vol. 12, p. 617,680
参考文献
Justus Liebigs Annalen der Chemie, , vol. 546, p. 277,291
