hydrogenchloride in methanol

ammonium formate; palladium on activated charcoal in tetrahydrofuran; methanol T=20°C;

1.1: CuCN*2LiBr / tetrahydrofuran / 20 °C 1.2: 92 percent / tetrahydrofuran / 1 h / 20 °C 2.1: tetrahydrofuran / -40 - 20 °C 3.1: ammonium formate / Pd/C / methanol; tetrahydrofuran / 20 °C View Scheme

1: tetrahydrofuran / -40 - 20 °C 2: ammonium formate / Pd/C / methanol; tetrahydrofuran / 20 °C View Scheme

tetrakis(triphenylphosphine) palladium(0); N,N-bis(trifluoromethanesulfonyl)aniline; hydrogen; sodium carbonate; lithium chloride; lithium diisopropyl amide; palladium on activated charcoal Yield given. Multistep reaction;