N-[(苄氧基)羰基]-L-苯丙氨酰-L-丙氨酰胺合成路线 （共 9 条）
反应条件
hydrogenchloride; water; phenol T=110°C; 17 h;
参考文献
Torkar, Ana; Lenarcic, Brigita; Lah, Tamara; Dive, Vincent; Devel, Laurent
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2968 - 2973
反应条件
hydrogenchloride; water; phenol T=110°C; 17 h;
参考文献
Torkar, Ana; Lenarcic, Brigita; Lah, Tamara; Dive, Vincent; Devel, Laurent
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2968 - 2973
反应条件
S166C-SCH2CH2NH3+; triethylamine; calcium chloride in water; N,N-dimethyl-formamide
Ambient temperature;
参考文献
Khumtaveeporn, Kanjai; DeSantis, Grace; Jones, J. Bryan
Tetrahedron Asymmetry, 1999 , vol. 10, # 13 p. 2563 - 2572
反应条件
1: N-benzyloxycarbonyl-L-phenylalanine With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=-25°C;
2: N-(tert-butoxycarbonyl)lalanine amide With sodium hydroxide in tetrahydrofuran; water
T=20°C; 2 h;
参考文献
Loeser, Reik; Frizler, Maxim; Schilling, Klaus; Guetschow, Michael
Angewandte Chemie - International Edition, 2008 , vol. 47, # 23 p. 4331 - 4334
反应条件
triethylamine; serine protease subtilisin Bacillus Lentus wildtype in water; N,N-dimethyl-formamide
T=20°C; pH=5.8; 24 h; Enzymatic reactionMES buffer;
参考文献
Matsumoto; Davis; Jones
Chemical Communications, 2001 , # 10 p. 903 - 904
反应条件
orange flavedo peptide amidase; ammonium hydrogen carbonate in water; acetonitrile
T=40°C; 72 h;
参考文献
Cerovsky, Vaclav; Kula, Maria-Regina
Angewandte Chemie - International Edition, 1998 , vol. 37, # 13-14 p. 1885 - 1887
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran
T=5°C;
2: With ammonium chloride in tetrahydrofuran; water
T=5°C; 0.5 h; Overall yield = 83 percent;
参考文献
Noguchi, Takuya; Jung, Seunghee; Imai, Nobuyuki
Tetrahedron Letters, 2014 , vol. 55, # 2 p. 394 - 396
反应条件
phosphate buffer; α-chymotrypsin in dimethyl sulfoxide
T=-24°C; pH=8.0; 1 h;
参考文献
Salam, Sayed Mohiuddin Abdus; Kagawa, Ken-Ichi; Kawashiro, Katsuhiro
Tetrahedron Asymmetry, 2006 , vol. 17, # 1 p. 22 - 29
反应条件
ammonia in methanol
48 h; Ambient temperature;
参考文献
Zaher, M. R.; El-Sharief, A. M. Sh.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 8 p. 740 - 743
