1: bromo-difluoroacetic acid,ethyl ester With chloro-trimethyl-silane in tetrahydrofuran 0.416667 h; 2: N-(benzhydryl)-1H-benzotriazolyl-1-methylamine in tetrahydrofuran T=25°C; 3 h;

1.1: TMSCl / tetrahydrofuran / 0.42 h 1.2: 86 percent / tetrahydrofuran / 3 h / 25 °C 2.1: 65 percent / t-BuMgCl / diethyl ether / 3 h / 0 - 20 °C View Scheme