tetrabutyl ammonium fluoride in tetrahydrofuran desilylation;

1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -78 - 20 °C 1.2: 90 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C 2.1: 99 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 12 h / 20 °C View Scheme

sulfuric acid; nitric acid in water T=20°C; 12 h;

sulfuric acid; nitric acid T=0°C; Nitration; acetylation;