1: With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 0.166667 h;
2: With boric acid trimethyl ester in tetrahydrofuran; hexanes
T=-78 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; hexanes; water
T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/9578 A2, 2004 ;
Location in patent: Page 44-45 ;
WO 2004/009578 A2