5-甲氧基-1-(4-甲氧基苯磺酰基)-1H-吲哚-3-甲醛合成路线 （共 10 条）
反应条件
1: 5-methoxyindole-3-carboxaldehyde With sodium hydroxide in dichloromethane
T=20°C;
2: 4methoxybenzenesulfonyl chloride in dichloromethane
T=20°C;
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 90 percent / phosphoryl chloride / 0 - 40 °C
2.1: NaOH / CH2Cl2 / 20 °C
2.2: 95 percent / CH2Cl2 / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 77 percent / Cu; quinoline / Heating
2.1: 90 percent / phosphoryl chloride / 0 - 40 °C
3.1: NaOH / CH2Cl2 / 20 °C
3.2: 95 percent / CH2Cl2 / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 45 percent / methanol / -10 °C
2.1: 37 percent / xylene / Heating
3.1: 99 percent / aq. NaOH / Heating
4.1: 77 percent / Cu; quinoline / Heating
5.1: 90 percent / phosphoryl chloride / 0 - 40 °C
6.1: NaOH / CH2Cl2 / 20 °C
6.2: 95 percent / CH2Cl2 / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
1.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
1.3: 65 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
1.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
1.3: 62 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 83 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
1.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
1.3: 84 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
1.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
1.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
1.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
1.3: 71 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 94 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
