反应条件
1.1: H2 / Pd/C / ethanol / 20 °C
2.1: LiAlH4 / tetrahydrofuran / 0 - 20 °C
3.1: NaH / tetrahydrofuran / Heating
4.1: acetonitrile / Heating
5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.3: 68 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 50 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282