1.1: 90 percent / phosphoryl chloride / 0 - 40 °C 2.1: NaOH / CH2Cl2 / 20 °C 2.2: 95 percent / CH2Cl2 / 20 °C 3.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 3.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 3.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 4.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: NaOH / CH2Cl2 / 20 °C 1.2: 95 percent / CH2Cl2 / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 2.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 3.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: 77 percent / Cu; quinoline / Heating 2.1: 90 percent / phosphoryl chloride / 0 - 40 °C 3.1: NaOH / CH2Cl2 / 20 °C 3.2: 95 percent / CH2Cl2 / 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 4.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 4.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 5.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: 99 percent / aq. NaOH / Heating 2.1: 77 percent / Cu; quinoline / Heating 3.1: 90 percent / phosphoryl chloride / 0 - 40 °C 4.1: NaOH / CH2Cl2 / 20 °C 4.2: 95 percent / CH2Cl2 / 20 °C 5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 5.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 6.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: NaH / tetrahydrofuran / Heating 2.1: acetonitrile / Heating 3.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 3.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 3.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 4.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: 45 percent / methanol / -10 °C 2.1: 37 percent / xylene / Heating 3.1: 99 percent / aq. NaOH / Heating 4.1: 77 percent / Cu; quinoline / Heating 5.1: 90 percent / phosphoryl chloride / 0 - 40 °C 6.1: NaOH / CH2Cl2 / 20 °C 6.2: 95 percent / CH2Cl2 / 20 °C 7.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 7.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 7.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 8.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 1.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 1.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 2.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme

1.1: acetonitrile / Heating 2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C 2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C 2.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C 3.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme