2-甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉-1-酮合成路线 （共 61 条）
反应条件
1: 98 percent / NaBH4 / tetrahydrofuran; methanol / 2 h
2: SOCl2 / benzene / 20 °C
3: dimethylsulfoxide; benzene / 2 h
4: 92 percent / 4N NaOH / ethanol / 20 h / Heating
5: SOCl2 / benzene / 2 h / 50 - 60 °C
6: 91 percent / benzene; pyridine / 20 °C
7: 85 percent / POCl3 / toluene / 3 h / Heating
8: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
9: 82 percent / acetonitrile / 1.25 h / Heating
10: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
11: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: 92 percent / 4N NaOH / ethanol / 20 h / Heating
2: SOCl2 / benzene / 2 h / 50 - 60 °C
3: 91 percent / benzene; pyridine / 20 °C
4: 85 percent / POCl3 / toluene / 3 h / Heating
5: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
6: 82 percent / acetonitrile / 1.25 h / Heating
7: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
8: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: SOCl2 / benzene / 20 °C
2: dimethylsulfoxide; benzene / 2 h
3: 92 percent / 4N NaOH / ethanol / 20 h / Heating
4: SOCl2 / benzene / 2 h / 50 - 60 °C
5: 91 percent / benzene; pyridine / 20 °C
6: 85 percent / POCl3 / toluene / 3 h / Heating
7: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
8: 82 percent / acetonitrile / 1.25 h / Heating
9: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
10: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: dimethylsulfoxide; benzene / 2 h
2: 92 percent / 4N NaOH / ethanol / 20 h / Heating
3: SOCl2 / benzene / 2 h / 50 - 60 °C
4: 91 percent / benzene; pyridine / 20 °C
5: 85 percent / POCl3 / toluene / 3 h / Heating
6: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
7: 82 percent / acetonitrile / 1.25 h / Heating
8: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
9: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: 91 percent / benzene; pyridine / 20 °C
2: 85 percent / POCl3 / toluene / 3 h / Heating
3: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
4: 82 percent / acetonitrile / 1.25 h / Heating
5: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
6: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: SOCl2 / benzene / 2 h / 50 - 60 °C
2: 91 percent / benzene; pyridine / 20 °C
3: 85 percent / POCl3 / toluene / 3 h / Heating
4: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
5: 82 percent / acetonitrile / 1.25 h / Heating
6: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
7: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
2: 82 percent / acetonitrile / 1.25 h / Heating
3: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
4: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: 85 percent / POCl3 / toluene / 3 h / Heating
2: 92 percent / methylene blue; O2 / CH2Cl2; methanol / 0.5 h / 15 °C / Irradiation
3: 82 percent / acetonitrile / 1.25 h / Heating
4: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
5: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
1: 82 percent / acetonitrile / 1.25 h / Heating
2: 92 percent / H2 / PtO2 / methanol / 3 h / 17 °C
3: 81 percent / O2 / methanol / 1 h
View Scheme
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Kanbayashi, Ryo; Tokuda, Masao; Suginome, Hiroshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6583 - 6596
反应条件
sodium periodate in methanol
T=20°C; 30 h;
参考文献
Moehrle; Rohn; Westle
Pharmazie, 2006 , vol. 61, # 5 p. 391 - 399
