2-甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉-1-酮合成路线 （共 61 条）
反应条件
1: 1) phosphoryl chloride / 1) reflux, 1 h; 2) methylene chloride, 0 deg C, overnight
2: 75 percent / sodium hydride / benzene
View Scheme
参考文献
Irie, Hiroshi; Shiina, Ayako; Fushimi, Tamaki; Katakawa, Jun'ichi; Fujii, Nobutaka; Yajima, Haruaki
Chemistry Letters, 1980 , p. 875 - 878
反应条件
1: acetonitrile / 2 h / 80 °C
2: 1) AgCl, 2) rat liver enzymes / 1) methanol, 2) 37 deg C, 2 h, pH 7.5
View Scheme
参考文献
Walterova; Preininger; Dolejs; et al.
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 3 p. 956 - 965
反应条件
1: 67 percent / activated MnO2 / CH2Cl2 / 4 h
2: 49 percent / aq. NaIO4 / methanol / 30 h / 20 °C
View Scheme
参考文献
Moehrle; Rohn; Westle
Pharmazie, 2006 , vol. 61, # 5 p. 391 - 399
反应条件
1: 79 percent / NaBH4 / methanol; H2O / 2 h / 20 °C
2: 67 percent / activated MnO2 / CH2Cl2 / 4 h
3: 49 percent / aq. NaIO4 / methanol / 30 h / 20 °C
View Scheme
参考文献
Moehrle; Rohn; Westle
Pharmazie, 2006 , vol. 61, # 5 p. 391 - 399
反应条件
1: 78 percent / sodium / liquid ammonia
2: 79 percent / NaBH4 / methanol; H2O / 2 h / 20 °C
3: 67 percent / activated MnO2 / CH2Cl2 / 4 h
4: 49 percent / aq. NaIO4 / methanol / 30 h / 20 °C
View Scheme
参考文献
Moehrle; Rohn; Westle
Pharmazie, 2006 , vol. 61, # 5 p. 391 - 399
反应条件
1: NaBH4 / aq. ethanol
2: DMSO, potassium t-butoxide / 24 h / Ambient temperature; Other reagent: NaH/DMSO
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Clephane, Janette; Wood, Michael L.; Holmes, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 275 - 282
反应条件
1: dimethylformamide / 0.75 h / Heating
2: NaBH4 / aq. ethanol
3: DMSO, potassium t-butoxide / 24 h / Ambient temperature; Other reagent: NaH/DMSO
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Clephane, Janette; Wood, Michael L.; Holmes, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 275 - 282
反应条件
1: 50 percent / PPA / 1.25 h / 100 °C
2: 72.4 percent / KOH / dimethylsulfoxide / 0.13 h
View Scheme
参考文献
Joshi, Vidya; Hari, M. I.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 1 p. 65 - 66
反应条件
Multistep reaction.;
参考文献
Chern, Meei-Shiou; Li, Wen-Ren
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8323 - 8326
反应条件
1: PPA / 3 h / 60 °C
2: 60 percent / KMnO4, 18-crown-6 / 0.5 h / Ambient temperature
View Scheme
参考文献
Venkov, Atanas P.; Ivanov, Ilian I.
Tetrahedron, 1996 , vol. 52, # 37 p. 12299 - 12308
