2-氯-3-氰基-4-甲基吡啶合成路线 （共 6 条）
反应条件
phosphorus pentachloride in water
参考文献
Gupton, Bernard Franklin
Patent: US2002/52507 A1, 2002 ;
反应条件
5 Pd(II)/C(eggshell); ammonium formate in methanol T=20°C; 72 h;
参考文献
Kiselev, Evgeny; Agama, Keli; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1682 - 1697
反应条件
1: acetic anhydride / toluene / 1 h / 45 °C 2: hydrogenchloride / acetic acid / 2 h / 55 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 20 p. 5298 - 5301
反应条件
1: trichlorophosphate / 8 h / 150 - 180 °C 2: 5 Pd(II)/C(eggshell); ammonium formate / methanol / 72 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 4 p. 1682 - 1697
反应条件
1.1: sulfuric acid / 4 h / 50 - 105 °C 1.2: 1.5 h / 60 - 65 °C 1.3: pH 7 / Cooling with ice 2.1: sodium hypochlorite; sodium hydroxide / methanol; water / 4 h / 10 - 60 °C View Scheme
参考文献
Ge, Xin; Chen, Han-Geng; Cao, Chang-Hui; Liu, Jin-Qiang; Qian, Chao; Chen, Xin-Zhi
Research on Chemical Intermediates, 2011 , vol. 37, # 6 p. 599 - 604
反应条件
sulfuric acid T=100°C; 1 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
Patent: EP1064265 B1, 2004 ;
Location in patent: Page 5 ;
