3-甲基-5-硝基-2-吡啶甲腈合成路线 （共 6 条）
反应条件
tert-butyl methyl ether; tetra-n-butylammonium nitrate; trifluoroacetic anhydride T=20°C; Nitration; 60 h;
参考文献
Afonso, Adriano; Weinstein, Jay; Kelly, Joseph; Wolin, Ronald; Rosenblum, Stuart B.; Connolly, Michael; Guzi, Timothy; James, Linda; Carr, Donna; Patton, Robert; Bishop, W.Robert; Kirshmeier, Paul; Liu; Heimark; Chen; Nomeir
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1845 - 1855
反应条件
trifluoroacetic anhydride in dichloromethane
参考文献
US2004/77605 A1, ;
US 20040077605 A1
反应条件
in N,N-dimethyl acetamide T=200°C; 2 h; Microwave irradiation;
参考文献
WO2007/65662 A2, ;
Page/Page column 46 ;
WO 2007/065662 A2
反应条件
iron; calcium chloride in ethanol T=20°C; Reduction; 18 h;
参考文献
Afonso, Adriano; Weinstein, Jay; Kelly, Joseph; Wolin, Ronald; Rosenblum, Stuart B.; Connolly, Michael; Guzi, Timothy; James, Linda; Carr, Donna; Patton, Robert; Bishop, W.Robert; Kirshmeier, Paul; Liu; Heimark; Chen; Nomeir
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1845 - 1855
反应条件
Calcium chloride in ethanol
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
反应条件
1.1: 85 percent / Fe; CaCl2 / aq. ethanol / 18 h / 20 °C 2.1: NaNO2; 48 percent HBr / H2O / 1 h / 0 °C 2.2: 78 percent / Cu / 0.5 h / Heating View Scheme
参考文献
Afonso, Adriano; Weinstein, Jay; Kelly, Joseph; Wolin, Ronald; Rosenblum, Stuart B.; Connolly, Michael; Guzi, Timothy; James, Linda; Carr, Donna; Patton, Robert; Bishop, W.Robert; Kirshmeier, Paul; Liu; Heimark; Chen; Nomeir
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1845 - 1855
