2-氟-3,5-二甲氧基苯甲酸甲酯合成路线 （共 3 条）
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=0 - 20°C;
参考文献
Chivikas Connolly, Cleo J.; Deur, Christopher James; Hamby, James Marino; Hoyer, Denton Wade; Limberakis, Chris; Reed, Jessica Elizabeth; Schroeder, Mel Conrad; Taylor, Clarke
Patent: US2004/19210 A1, 2004 ;
Location in patent: Page 13 ;
US 20040019210 A1
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=0 - 20°C;
参考文献
IRM LLC
Patent: WO2008/8747 A1, 2008 ;
Location in patent: Page/Page column 38 ;
WO 2008/008747 A1
反应条件
1: With sodium hydroxide in ethanol
24 h; Heating / reflux;
2: With hydrogenchloride in water
参考文献
Chivikas Connolly, Cleo J.; Deur, Christopher James; Hamby, James Marino; Hoyer, Denton Wade; Limberakis, Chris; Reed, Jessica Elizabeth; Schroeder, Mel Conrad; Taylor, Clarke
Patent: US2004/19210 A1, 2004 ;
Location in patent: Page 13 ;
US 20040019210 A1
