1: 4-methyl-3-buten-2-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: benzaldehyde in tetrahydrofuran; hexane T=-78°C; 0.25 h;

anhydrous propionitrile; (2R,3R)-3-hydroxy-2-lt;(2,6-diisopropoxybenzoyl)oxygt;butanedioic acid; 3,4,5-trimethoxyphenylboronic acid T=-78 - 20°C; Mukaiyama aldol-like reaction; 19 h;

1: With samarium diiodide in tetrahydrofuran T=0°C; 0.333333 h; Inert atmosphere; 2: With oxygen 3: With boric acid in water T=20°C; 0.5 h; Inert atmosphere; chemoselective reaction;

disodium hydrogenphosphate; oxygen; copper(l) chloride; palladium dichloride in ethylene glycol dimethyl ether T=50°C; 8 h;