2-氯-3-氰基-5,6-二甲基吡啶合成路线 （共 4 条）
反应条件
trichlorophosphate T=20°C; 13 h;
参考文献
REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu
Patent: WO2006/73973 A2, 2006 ;
Location in patent: Page/Page column 255 ;
反应条件
1: butanone; formic acid ethyl ester With sodium methylate in methanol; diethyl ether T=4 - 20°C; 6.75 h; 2: 2-cyano-acetamide With piperidine; acetic acid in water 17 h; Reflux;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2123652 A1, 2009 ;
Location in patent: Page/Page column 47 ;
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol
参考文献
Nishikawa; Shindo; Ishii; Nakamura; Kon; Uno
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 583 - 593
反应条件
potassium carbonate in N,N-dimethyl-formamide
24 h; Heating / reflux;
参考文献
REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu
Patent: WO2006/73973 A2, 2006 ;
Location in patent: Page/Page column 255-256 ;
