5-溴-1H-吲唑-1-甲酸叔丁酯合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C;
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1476 - 1479
反应条件
potassium acetate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate in 1,4-dioxane T=110°C;
参考文献
GLAXOSMITHKLINE LLC; CHAUDHARI, Amita, M.; HALLMAN, Jason; LAUDEMAN, Christopher, P.; MUSSO, David, Lee; PARRISH, Cynthia, A.
Patent: WO2011/66211 A1, 2011 ;
Location in patent: Page/Page column 69-70 ;
WO 2011/066211 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C;
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1480 - 1483
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 95 °C
2: methanol; potassium hydroxide
View Scheme
参考文献
Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1476 - 1479
