2-甲氧基-6-甲基苯甲酸乙酯合成路线 （共 20 条）
反应条件
1: 1.) LDA, 2.) HMPA / 1.) THF, -70 deg C, 10 min, 2.) THF, -70 deg 2: 72 percent / tBuSLi / 7 h / Heating View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 228 - 240
反应条件
1: 54 percent / Br2 / CCl4 / 17 h / Heating; Irradiation 2: 25 percent / aq. NaOH / Heating View Scheme
参考文献
Islam, Md. Rabiul; Joule, John A.
Journal of Chemical Research, Miniprint, 1991 , # 2 p. 367 - 378
反应条件
1: 1.) LiN(i-Pr)2, 2.) HMPA
2: H2, quinoline / Pd/BaSO4 / ethyl acetate
3: lithium t-butyl thiolate / dimethylformamide
View Scheme
参考文献
Tyman, John H.P.; Visani
Chemistry and Physics of Lipids, 1997 , vol. 85, # 2 p. 157 - 174
反应条件
1: 97 percent / DIBAL-H / hexane; diethyl ether / 0.17 h / -78 °C
2: 86 percent / MnO2 / benzene / 5 h / Heating
3: 41 percent / LiCl / dimethylformamide / 15 h / Heating
View Scheme
参考文献
Nakanishi, Tsutomu; Inatomi, Yuka; Murata, Hiroko; Iida, Naoki; Inada, Akira; Lang, Frank A; Murata, Jin
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 10 p. 1358 - 1361
反应条件
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / Heating; Irradiation
2: 9percent HCl / acetic acid / 12 h / Heating
View Scheme
参考文献
Hauser, Frank M.; Rhee, Richard P.
Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3061 - 3068
反应条件
2: 95 percent
3: 96 percent
View Scheme
参考文献
Matsuda, Fuyuhiko; Kawasaki, Motoji; Ohsaki, Masako; Yamada, Kaoru; Terashima, Shiro
Tetrahedron, 1988 , vol. 44, # 18 p. 5745 - 5760
反应条件
2: 78 percent / NaH / t-BuOH / toluene / 1 h / 80 °C
View Scheme
参考文献
Lewis, Christopher N.; Spargo, Peter L.; Staunton, James
Synthesis, 1986 , # 11 p. 944 - 946
反应条件
1: 10percent aq. NaOH / ethanol / 24 h / Heating
2: (COCl)2 / benzene / Ambient temperature
View Scheme
参考文献
Chatterjea, J. N.; Singh, K. R. R. P.; Jha, I. S.; Prasad, Y.; Shaw, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 796 - 798
反应条件
1: 55 percent
2: 90 percent / HCl, H2O
View Scheme
参考文献
Julia, Marc; Rolando, Christian; Vincent, Emmanuel; Xu, Jin Zhu
Heterocycles, 1989 , vol. 28, # 1 p. 71 - 74
反应条件
1: 97 percent / DIBAL-H / hexane; diethyl ether / 0.17 h / -78 °C
2: 86 percent / MnO2 / benzene / 5 h / Heating
View Scheme
参考文献
Nakanishi, Tsutomu; Inatomi, Yuka; Murata, Hiroko; Iida, Naoki; Inada, Akira; Lang, Frank A; Murata, Jin
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 10 p. 1358 - 1361
