6-氯哒嗪-3-甲酸甲酯合成路线 （共 16 条）
反应条件
methanol in dichloromethane T=0°C; 1 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/28452 A1, 2005 ;
Location in patent: Page/Page column 84 ;
WO 2005/028452 A1
反应条件
trichlorophosphate 2.5 h; Heating / reflux;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34440 A2, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/034440 A2
反应条件
1: 6-chloropyridazine-3-carboxylic acid With thionyl chloride 3 h; Heating / reflux; 2: sodium methylate in methanol T=20°C;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 149 ;
WO 2004/014881 A2
反应条件
1: 6-chloropyridazine-3-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane; ethyl acetate T=20°C; 4 h; 2: methanol in dichloromethane; ethyl acetate 0.25 h;
参考文献
WO2007/71023 A1, ;
Page/Page column 36 ;
WO 2007/071023 A1
反应条件
1: 6-chloropyridazine-3-carboxylic acid With oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=20°C; 2: methanol in dichloromethane; N,N-dimethyl-formamide 0.5 h;
参考文献
WO2014/28669 A1, ;
Paragraph 00320 ;
反应条件
in dichloromethane; ethyl acetate 0.25 h;
参考文献
WO2007/9236 A1, ;
Page/Page column 43 ;
反应条件
1: 97 percent / NH3 / methanol / 0.5 h / 0 °C 2: dioxane / 40 h / Heating 3: 73 percent / BF3*Et2O / 21 h / 100 - 110 °C View Scheme
参考文献
Konno, Shoetsu; Sagi, Mataichi; Siga, Futoshi; Yamanaka, Hiroshi
Heterocycles, 1992 , vol. 34, # 2 p. 225 - 228
参考文献
Konno, Shoetsu; Sagi, Mataichi; Siga, Futoshi; Yamanaka, Hiroshi
Heterocycles, 1992 , vol. 34, # 2 p. 225 - 228
反应条件
sodium hydride in tetrahydrofuran 6.5 h; Heating;
参考文献
Heterocycles, , vol. 34, # 2 p. 225 - 228
反应条件
1: 97 percent / NH3 / methanol / 0.5 h / 0 °C 2: dioxane / 40 h / Heating View Scheme
参考文献
Heterocycles, , vol. 34, # 2 p. 225 - 228
