6-氯哒嗪-3-甲酸甲酯合成路线 （共 16 条）
反应条件
ammonia in methanol T=0°C; 0.5 h;
参考文献
Konno, Shoetsu; Sagi, Mataichi; Siga, Futoshi; Yamanaka, Hiroshi
Heterocycles, 1992 , vol. 34, # 2 p. 225 - 228
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran T=0°C; 0.333333 h; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C; 3: With sodium hydrogencarbonate in tetrahydrofuran; water T=20°C;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION; SAKURAI, Osamu; SARUTA, Kunio; HAYASHI, Norimitsu; GOI, Takashi; MOROKUMA, Kenji; TSUJISHIMA, Hidekazu; SAWAMOTO, Hiroaki; SHITAMA, Hiroaki; IMASHIRO, Ritsuo
Patent: WO2012/81736 A1, 2012 ;
Location in patent: Page/Page column 82 ;
WO 2012/081736 A1
反应条件
1: 97 percent / NH3 / methanol / 0.5 h / 0 °C 2: dioxane / 40 h / Heating 3: 73 percent / BF3*Et2O / 21 h / 100 - 110 °C View Scheme
参考文献
Konno, Shoetsu; Sagi, Mataichi; Siga, Futoshi; Yamanaka, Hiroshi
Heterocycles, 1992 , vol. 34, # 2 p. 225 - 228
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
T=50°C; 20 h;
参考文献
Yamanaka; Mizugaki; Sakamoto; et al.
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4549 - 4553
反应条件
1: 80 percent / Pd(PPh3)2Cl2/CuI/Et3N / 20 h / 50 °C
2: 96 percent / H2 / 5percent Pd-charcoal / methanol
View Scheme
参考文献
Konno, Shoetsu; Sagi, Mataichi; Siga, Futoshi; Yamanaka, Hiroshi
Heterocycles, 1992 , vol. 34, # 2 p. 225 - 228
反应条件
1: 80 percent / Pd(PPh3)2Cl2/CuI/Et3N / 20 h / 50 °C
2: 96 percent / H2 / 5percent Pd-charcoal / methanol
3: 3N NaOH / Ambient temperature; pH: 3.2
View Scheme
参考文献
Yamanaka; Mizugaki; Sakamoto; et al.
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4549 - 4553
