4-[[2,3-二氢-5,6-二甲氧基-2-(甲氧羰基)-1-氧代-1H-茚-2-基]甲基]-1-哌啶甲酸叔丁酯合成路线 (共 1 条)
反应条件
1: 5,6-Dimethoxy-1-oxoindane-2-carboxylic acid methyl ester With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: 4-iodomethyl-piperidine-1-carboxylic acid tert-butyl ester in DMF (N,N-dimethyl-formamide)
T=20 - 50°C; 5.5 h;
参考文献
CHEMAGIS LTD.
Patent: EP1386607 A1, 2004 ;
Location in patent: Page/Page column 10 ;