4-羟基哌啶-1-甲酸乙酯合成路线 （共 6 条）
反应条件
2-methyl-1-bromopropane; magnesium in diethyl ether 10 h; Heating;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 50, # 7 p. 1484 - 1497
反应条件
TEA in chloroform 18 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 22 p. 4118 - 4134
反应条件
potassium hydroxide in ethanol T=130°C; 3 h; Heating;
参考文献
Sindelar; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1484 - 1497
反应条件
triethylamine in ethyl acetate T=3 - 20°C; 1 h;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2008/140090 A1, 2008 ;
Location in patent: Page/Page column 31 ;
反应条件
N-ethyl-N,N-diisopropylamine T=80°C; 3 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 34, # 2 p. 549 - 552
反应条件
potassium carbonate in water
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4200641 A1, 1980 ;
