2-氯-n-[(二甲基氨基)亚甲基]-4-吡啶羧酰胺合成路线 （共 2 条）
参考文献
JANSSEN PHARMACEUTICA, NV; KUO, Gee-Hong; DEANGELIS, Alan; WANG, Aihua; ZHANG, Yan; EMANUEL, Stuart, L.; MIDDLETON, Steve, A.
Patent: WO2004/9562 A1, 2004 ;
Location in patent: Page 33-35 ;
WO 2004/009562 A1
反应条件
1: (3-Chlorophenyl)guanidine nitrate With potassium tert-butylate in tetrahydrofuran
T=20°C; 0.25 h;
2: 2-chloro-N-dimethylaminomethyleneisonicotinamide in tetrahydrofuran
T=20 - 70°C; 0.5 h;
参考文献
JANSSEN PHARMACEUTICA, NV; KUO, Gee-Hong; DEANGELIS, Alan; WANG, Aihua; ZHANG, Yan; EMANUEL, Stuart, L.; MIDDLETON, Steve, A.
Patent: WO2004/9562 A1, 2004 ;
Location in patent: Page 33-35 ;
WO 2004/009562 A1
