N-(3-氯苯基)-4-(2-氯-4-吡啶)-1,3,5-噻嗪-2-胺合成路线 （共 5 条）
反应条件
1: (3-Chlorophenyl)guanidine nitrate With potassium tert-butylate in tetrahydrofuran
T=20°C; 0.25 h;
2: 2-chloro-N-dimethylaminomethyleneisonicotinamide in tetrahydrofuran
T=20 - 70°C; 0.5 h;
参考文献
JANSSEN PHARMACEUTICA, NV; KUO, Gee-Hong; DEANGELIS, Alan; WANG, Aihua; ZHANG, Yan; EMANUEL, Stuart, L.; MIDDLETON, Steve, A.
Patent: WO2004/9562 A1, 2004 ;
Location in patent: Page 33-35 ;
WO 2004/009562 A1
反应条件
in isopropyl alcohol
T=20°C;
参考文献
SYNGENTA PARTICIPATIONS AG
Patent: WO2004/84634 A1, 2004 ;
Location in patent: Page 46 ;
反应条件
1: 2-chloro-isonicotinamide; N,N-dimethyl-formamide dimethyl acetal T=100°C; 1.16667 h;
2: (3-Chlorophenyl)guanidine nitrate With potassium tert-butylate in tetrahydrofuran
T=20°C; 2 h;
参考文献
JANSSEN PHARMACEUTICA, NV; KUO, Gee-Hong; DEANGELIS, Alan; WANG, Aihua; ZHANG, Yan; EMANUEL, Stuart, L.; MIDDLETON, Steve, A.
Patent: WO2004/9562 A1, 2004 ;
Location in patent: Page 35; 36 ;
WO 2004/009562 A1
反应条件
in 1,4-dioxane
2 h; Heating / reflux;
参考文献
DOW AGROSCIENCES LLC
Patent: WO2005/33095 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 61 percent / 1 h / 100 °C
2: 26 mg / t-BuOK / tetrahydrofuran / 0.5 h / 20 - 70 °C
View Scheme
参考文献
Kuo, Gee-Hong; DeAngelis, Alan; Emanuel, Stuart; Wang, Aihua; Zhang, Yan; Connolly, Peter J.; Chen, Xin; Gruninger, Robert H.; Rugg, Catherine; Fuentes-Pesquera, Angel; Middleton, Steven A.; Jolliffe, Linda; Murray, William V.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4535 - 4546
