2-氯-5,6,7,8-四氢喹啉-3-甲腈合成路线 （共 2 条）
反应条件
1: With sodium acetate; zinc in acetic acid T=60°C; 2 h; 2: With water in acetic acid T=60°C; 5 h;
参考文献
F. HOFFMANN-LA ROCHE AG; SIENA BIOTECH S.P.A; HILPERT, Hans; NARQUIZIAN, Robert; PINARD, Emmanuel; POLARA, Alessandra; ROGERS-EVANS, Mark; WOLTERING, Thomas; WOSTL, Wolfgang
Patent: WO2012/156284 A1, 2012 ;
Location in patent: Page/Page column 133 ;
反应条件
1: With trichlorophosphate
T=20°C; 13 h; Heating / reflux;
2: With sodium hydrogencarbonate in water
参考文献
REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu
Patent: WO2006/73973 A2, 2006 ;
Location in patent: Page/Page column 244-245 ;
