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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
652990-07-3
合成路线
(共 6 条)
652990-10-8
→
反应条件
652990-07-3
反应条件
1: With darco G-60 in ethanol T=50°C; 0.333333 h; 2: With hydrogen; palladium 10 on activated carbon in ethanol P=1551.49 Torr; 10 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/95328 A1, 2005 ;
Location in patent: Page/Page column 25-26 ;
13472-00-9
2-(4-氨基苯)乙胺
→
反应条件
652990-07-3
反应条件
1: toluene 2: sodium tetrahydroborate / tetrahydrofuran; methanol 3: n-butyllithium / tetrahydrofuran / -78 °C 4: toluene / Reflux 5: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Jacobsen, John R.; Choi, Seok Ki; Combs, Jesse; Fournier, Eric J.L.; Klein, Uwe; Pfeiffer, Juergen W.; Thomas, G. Roger; Yu, Cecile; Moran, Edmund J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1213 - 1218
344466-46-2
→
反应条件
652990-07-3
反应条件
1: sodium tetrahydroborate / tetrahydrofuran; methanol 2: n-butyllithium / tetrahydrofuran / -78 °C 3: toluene / Reflux 4: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Jacobsen, John R.; Choi, Seok Ki; Combs, Jesse; Fournier, Eric J.L.; Klein, Uwe; Pfeiffer, Juergen W.; Thomas, G. Roger; Yu, Cecile; Moran, Edmund J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1213 - 1218
344466-47-3
→
反应条件
652990-07-3
反应条件
1: n-butyllithium / tetrahydrofuran / -78 °C 2: toluene / Reflux 3: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Jacobsen, John R.; Choi, Seok Ki; Combs, Jesse; Fournier, Eric J.L.; Klein, Uwe; Pfeiffer, Juergen W.; Thomas, G. Roger; Yu, Cecile; Moran, Edmund J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1213 - 1218
1355183-83-3
→
反应条件
652990-07-3
反应条件
1: toluene / Reflux 2: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Jacobsen, John R.; Choi, Seok Ki; Combs, Jesse; Fournier, Eric J.L.; Klein, Uwe; Pfeiffer, Juergen W.; Thomas, G. Roger; Yu, Cecile; Moran, Edmund J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1213 - 1218
652990-07-3
→
反应条件
804518-03-4
反应条件
hydrogenchloride in water; isopropyl alcohol T=40°C; 6.16667 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/95328 A1, 2005 ;
Location in patent: Page/Page column 26 ;