caesium carbonate in DMF (N,N-dimethyl-formamide)

1: N-(4-methoxybenzyl)urea With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; 2: chloroacetic acid ethyl ester in N,N-dimethyl-formamide T=20 - 70°C; 21 h;

1.1: water; acetic acid / 20 - 55 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 2.2: 21 h / 20 - 70 °C View Scheme