4-(三丁基锡烷基)-2-甲基噻唑合成路线 (共 1 条)
反应条件
1: 4-bromo-2-methylthiazole With n-butyllithium in hexanes; diethyl ether
T=-78°C; 1.33333 h;
2: tributyltin chloride in hexanes; diethyl ether
T=-78°C; 1.25 h; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2007/14922 A1, 2007 ;
Location in patent: Page/Page column 103 ;