甲基2-乙基-6-羟基-2,3-二氢-1-苯并呋喃-2-羧酸酯合成路线 （共 3 条）
反应条件
1.1: Cs2CO3 / dimethylformamide / 50 - 150 °C
2.1: H2 / Pd/C / ethanol / 72 h / 2327.17 Torr
3.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
3.2: tetrahydrofuran / -78 - 25 °C
4.1: BBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
1.1: H2 / Pd/C / ethanol / 72 h / 2327.17 Torr
2.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
2.2: tetrahydrofuran / -78 - 25 °C
3.1: BBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
1.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / -78 - 25 °C
2.1: BBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
