3-氨基-5-异丙氧基苯酚合成路线 （共 5 条）
反应条件
sodium thiomethoxide in 1-methyl-pyrrolidin-2-one
T=140°C; 1 h;
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: 55 percent / NaSMe / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C
2: PPh3; DEAD / tetrahydrofuran / 0.25 h / 20 °C
3: NaSMe / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: PPh3; DEAD / tetrahydrofuran / 0.25 h / 20 °C
2: NaSMe / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu reaction; 0.25 h;
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu reaction; 15 h;
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
