4-甲氧基噻吩-3-羧酸甲酯合成路线 （共 4 条）
反应条件
1: 4-Bromthiophen-3-carbonsaeuremethylester; sodium methylate With sodium iodide; copper(II) oxide in methanol 68 h; Heating; 2: diazomethane in diethyl ether T=0°C;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
sulfuryl dichloride in dichloromethane 1.5 h;
参考文献
Rossy, Phillip A.; Hoffmann, Werner; Mueller, Norbert
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 617 - 620
反应条件
sodium hydroxide in methanol 0.25 h; Heating;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
