4,4-二甲基-5-亚甲基二氢呋喃-2(3H)-酮合成路线 （共 11 条）
反应条件
palladium dichloride
参考文献
Jacobi, Peter A.; Liu, Hui
Journal of the American Chemical Society, 1999 , vol. 121, # 9 p. 1958 - 1959
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in benzene T=70 - 80°C; 3 h;
参考文献
Guenther, Hans Juergen; Guntrum, Eberhard; Jaeger, Volker
Liebigs Annalen der Chemie, 1984 , # 1 p. 15 - 30
反应条件
sodium carbonate T=160 - 180°C; P=10 Torr;
参考文献
Joshi, G. S.; Deshmukh, A. R. A. S.; Kulkarni, G. H.
Synthetic Communications, 1988 , vol. 18, # 6 p. 559 - 566
反应条件
oxygen; copper dichloride; palladium dichloride in water; N,N-dimethyl-formamide from r.t. to 60 deg C;
参考文献
Tetrahedron Letters, , vol. 27, # 27 p. 3165 - 3168
反应条件
1: 82 percent / Br2 / CH2Cl2 / 1.5 h / -70 °C 2: 1.) sodium hydride / 1) benzene, 25 deg C, 1.5 h; 2) benzene, reflux (2 h), 25 deg C (overnight) 3: 89.9 percent / hydrogen peroxide / methanol / 4 h / 25 °C 4: 74 percent / sodium carbonate / 160 - 180 °C / 10 Torr View Scheme
参考文献
Synthetic Communications, , vol. 18, # 6 p. 559 - 566
反应条件
1: 1.) sodium hydride / 1) benzene, 25 deg C, 1.5 h; 2) benzene, reflux (2 h), 25 deg C (overnight) 2: 89.9 percent / hydrogen peroxide / methanol / 4 h / 25 °C 3: 74 percent / sodium carbonate / 160 - 180 °C / 10 Torr View Scheme
参考文献
Synthetic Communications, , vol. 18, # 6 p. 559 - 566
反应条件
1: 89.9 percent / hydrogen peroxide / methanol / 4 h / 25 °C 2: 74 percent / sodium carbonate / 160 - 180 °C / 10 Torr View Scheme
参考文献
Synthetic Communications, , vol. 18, # 6 p. 559 - 566
反应条件
1: 1) Propionsaeure, 2a) conc. HCl, 2b) H2O/methanol/KOH / 1) 140-150 deg C, 2a) 110 deg C, 2b) reflux, 2h 2: 99 percent / NaHCO3, KI, I2 / H2O / 12 h / Ambient temperature 3: 81 percent / DBU / benzene / 3 h / 70 - 80 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , # 1 p. 15 - 30
反应条件
1) alkylation; 2) pyridine, heating; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 26, # 29 p. 3503 - 3506
反应条件
tin(IV) chloride in dichloromethane
Ambient temperature;
参考文献
Guntrum, Eberhard; Kuhn, Walter; Spoenlein, Wolfgang; Jaeger, Volker
Synthesis, 1986 , # 11 p. 921 - 925
