1: in tetrahydrofuran
T=0 - 20°C; Grignard reaction;
2: With hydrogenchloride; water in tetrahydrofuran
Grignard reaction;
3: With sodium hydroxide in tetrahydrofuran; water
T=0°C;
Manikumar, Govindarajan; Wadkins, Randy M.; Bearss, David; Von Hoff, Daniel D.; Wani, Mansukhlal C.; Wall, Monroe E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5377 - 5381
1: hydrogenchloride; iron / ethanol; water / 2 h / 80 °C
2: tetrahydrofuran; diethyl ether
3: CuCl2*H2O; potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C
View Scheme
参考文献
Yan, Yizhe; Wang, Zhiyong
Chemical Communications, 2011 , vol. 47, # 33 p. 9513 - 9515
